Rev Med UAS
Rev Med UAS; Vol. 14 No. 3. Julio-Septiembre 2024
ISSN 2007-8013

Talidomida, revisión: uso clínico y actualización

Thalidomide, review: clinical use and update

Víctor Fernando Muñoz-Estrada1, Edwin Daniel Maldonado-Domínguez2, Wendoline Almeida-Vega2*, Lariza Meza-Machado2.

  1. Médico adscrito al servicio de Dermatología y Micología del Centro de Investigación y Docencia en Ciencias de la Salud, Hospital Civil de Culiacán, UAS.
  2. Médico residente de Dermatología y Micología del Centro de Investigación y Docencia en Ciencias de la Salud, Hospital Civil de Culiacán, UAS.

*Autor de correspondencia:Dra. Wendoline Almeida Vega
Domicilio: Calle Eustaquio Buelna No. 91, Colonia Gabriel Leyva C.P. 80030 Culiacán, Sinaloa
Tel. (668) 256172 Correo: wendoline.av@gmail.com

DOI http://dx.doi.org/10.28960/revmeduas.2007-8013.v14.n3.009

Texto Completo PDF

Recibido 23 de abril 2024, aceptado 20 de junio 2024

RESUMEN
La talidomida es un fármaco con una historia impactante en la medicina y que causó desastres en gran parte de la población, ya que fue administrada a las personas incorrectas, sin embargo, a lo largo del tiempo se ha reposicionado y en la actualidad se utiliza en múltiples patologías dermatológicas, con resultados terapéuticos excelentes debido a sus propiedades antiinflamatorias, antiangiogénicas e inmunomoduladoras. El objetivo de esta revisión es describir la historia, farmacología, mecanismo de acción, indicaciones en Dermatología y efectos adversos de la talidomida. Obteniendo como resultado que la talidomida tiene múltiples indicaciones en enfermedades dermatológicas así como en otras áreas de la salud.
Palabras clave: Talidomida, dermatología, mecanismo de acción.

ABSTRACT
Thalidomide is a drug with a shocking history in medicine and that caused disasters in a large part of the population, since it was administered to the wrong people, however, over time it has been repositioned and is currently used in multiple dermatological pathologies, with excellent therapeutic results due to its anti-inflammatory, antiangiogenic and immunomodulatory properties. The objective of this review is to describe the history, pharmacology, mechanism of action, indications in dermatology and adverse effects of thalidomide.
Keywords: Thalidomide, dermatology, mechanism of action.

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