Rev Med UAS
Rev Med UAS; Vol. 14: No. 2. Abril-Junio 2024
ISSN 2007-8013

Influencia del microbioma intestinal asociado al desarrollo de enfermedades neurodegenerativas: Revisión de la literatura/strong>

Influence of the intestinal microbiome associated with the development of neurodegenerative diseases: Literature Review

Ángel R. Rábago-Monzón1,3, Alexis M. Rodríguez-Rosas1, Diana L. Baldenebro-Félix3, Josué Camberos-Barraza1,3, Alma M. Guadrón-Llanos1, Víctor M. Ruíz-Ruelas1, Alberto K. De la Herrán-Arita1, Javier A. Magaña-Gómez2, Carla E. Angulo-Rojo1*

  1. Facultad de Medicina, Universidad Autónoma de Sinaloa, Culiacán, Sinaloa, México.
  2. Facultad de Ciencias de la Nutrición y Gastronomía, Universidad Autónoma de Sinaloa, Culiacán, México.
  3. Doctorado en Ciencias en Biomedicina Molecular, Facultad de Medicina, Universidad Autónoma de Sinaloa, Culiacán, México.

*Autor de correspondencia:Carla E. Angulo-Rojo, Facultad de Medicina, Universidad Autónoma de Sinaloa. Culiacán, Sinaloa, México. Email: carla.angulo@uas.edu.mx ORCID: 0000-0002-5097-2444

DOI http://dx.doi.org/10.28960/revmeduas.2007-8013.v14.n2.008

Texto Completo PDF

Recibido 02 de octubre 2023, aceptado 27 de febrero 2023

RESUMEN
En los últimos años, las investigaciones en el campo de la neurociencia han revelado que enfermedades neurodegenerativas presentan una estrecha relación con el microbioma intestinal. Estudios clínicos y preclínicos, sugieren que el microbioma intestinal desempeña un papel crucial en el cerebro y revelan que un desequilibrio en su composición puede estar vinculado a enfermedades neurodegenerativas, cuyos mecanismos subyacentes aún requieren mayor estudio. Esta revisión tiene como objetivo destacar la relación entre el microbioma intestinal y las enfermedades neurodegenerativas, así como profundizar en la comprensión de su función y mecanismos relevantes. Además, se discuten las aplicaciones actuales y las perspectivas futuras de terapias relacionadas con el microbioma, las cuales, podrían abrir nuevas vías en la investigación de enfermedades neurodegenerativas.
Palabras claves: microbioma, microbiota, enfermedad neurodegenerativa, neurociencias.

ABSTRACT
Recent neuroscience research has shown a strong connection between neurodegenerative illnesses and the gut flora. Research indicates that the gut microbiome significantly influences the brain and shows that an abnormal composition may be associated with neurodegenerative illnesses, which necessitate more investigation into their root causes. This review seeks to emphasize the connection between the gut microbiota and neurodegenerative illnesses, while also aiming to enhance comprehension of their roles and associated processes. The article explores the present uses and potential advancements of microbiome-based treatments, which may lead to new avenues in studying neurodegenerative disorders.
Keywords: Microbiome, microbiota, neurodegenerative disease, neurosciences.

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