Rev Med UAS
Rev Med UAS; Vol. 14: No. 2. Abril-Junio 2024
ISSN 2007-8013
Recurrencia de dismenorrea en pacientes con endometriosis peritoneal tratadas con peritonectomía laparoscópica
Recurrence of dysmenorrhea in patients with peritoneal endometriosis treated with laparoscopic peritonectomy
Marco Antonio López-Zepeda1, Francisco Manuel Robles-López2, Manuel Antonio López-de la Torre1, Fred Morgan-Ortiz1,2*
- Hospital Puerta de Hierro en Guadalajara, Jalisco.
- Departamento de Ginecología y Obstetricia del Centro de Investigación y Docencia en Ciencias de la Salud, Universidad Autónoma de Sinaloa.
*Autor de correspondencia: Dr. Fred Morgan-Ortiz.
Eustaquio Buelna, No. 91. Col. Gabriel Leyva. CP: 80030 Culiacán Rosales, Sin.
Correo electrónico: fmorganaortiz@uas.edu.mx; Tel. 6671981873
DOI http://dx.doi.org/10.28960/revmeduas.2007-8013.v14.n2.002
Texto Completo PDF
Recibido 14 de noviembre 2023, aceptado 18 de diciembre 2023
RESUMEN
Objetivo: Determinar el efecto de la peritonectomía sobre el dolor pélvico en pacientes con endometriosis.
Pacientes y método: Estudio prospectivo, longitudinal y observacional en pacientes con endometriosis peritoneal y dolor pélvico sometidas a peritonectomía en la Clínica de Excelencia de Endometriosis en Guadalajara, Jalisco. Se evaluó la intensidad del dolor mediante la escala visual análoga (EVA) antes y 12 meses después del procedimiento. También se clasificó el estadio de la enfermedad con ASRM y AAGL, y se analizaron variables secundarias como gestaciones, evolución de la dismenorrea, cirugías previas, manejo médico, duración del procedimiento, pérdida sanguínea y complicaciones.
Resultados: Se realizaron 213 procedimientos, con una edad media de 32.9 años (rango 15-54). De las pacientes, 106 (49.8%) estaban casadas y 107 (50.2%) solteras. Las nuligestas fueron 147 (69.01%) y el 46.4% de las pacientes estuvo libre de dismenorrea entre 2 y 4 años tras la cirugía. Los estadios de enfermedad fueron: rASM (I: 4.69%, II: 22.5%, III: 30.04%, IV: 42.7%) y AAGL (I: 4.69%, II: 14.55%, III: 16.43%, IV: 64.31%). La pérdida sanguínea osciló entre 10 y 700 ml, y el tiempo quirúrgico promedio fue de 177.5 minutos. La media de dolor antes y después de la cirugía fue de 9.0 y 1.0, respectivamente, con una reducción promedio de 7.9 puntos en la EVA (p<0.001).
Conclusiones: La peritonectomía laparoscópica es efectiva en el manejo de la endometriosis peritoneal, con un 46.4% de ausencia de dismenorrea a 2 años y una disminución media de 7.9 puntos en la intensidad del dolor.
Palabras clave: Endometriosis, laparoscopia, dismenorrea, recurrencia.
ABSTRACT
Objective: Determine the effect of peritonectomy on pelvic pain in patients with endometriosis.
Patients and method: Prospective, longitudinal and observational study in patients with peritoneal endometriosis and pelvic pain undergoing peritonectomy at the Endometriosis Clinic of Excellence in Guadalajara, Jalisco. Pain intensity was evaluated using the visual analogue scale (VAS) before and 12 months after the procedure. The stage of the disease was also classified with ASRM and AAGL, and secondary variables such as pregnancies, evolution of dysmenorrhea, previous surgeries, medical management, duration of the procedure, blood loss and complications were analyzed.
Results: 213 procedures were performed, with a mean age of 32.9 years (range 15-54). Of the patients, 106 (49.8%) were married and 107 (50.2%) were single. Nuligpes were 147 (69.01%) and 46.4% of the patients were free of dysmenorrhea between 2 and 4 years after surgery. The disease stages were: rASM (I: 4.69%, II: 22.5%, III: 30.04%, IV: 42.7%) and AAGL (I: 4.69%, II: 14.55%, III: 16.43%, IV: 64.31%). Blood loss ranged from 10 to 700 ml, and the average surgical time was 177.5 minutes. The mean pain before and after surgery was 9.0 and 1.0, respectively, with an average reduction of 7.9 points on the VAS (p<0.001).
Conclusions: Laparoscopic peritonectomy is effective in the management of peritoneal endometriosis, with a 46.4% absence of dysmenorrhea at 2 years and an average decrease of 7.9 points in pain intensity.
Keywords: Endometriosis, laparoscopy, dysmenorrhea, recurrence.
Referencias
- Chamié L, Blasbalg R, Pereira R. Findings of pelvic endometriosis at transvaginal US, MR imaging, and laparoscopy. Radio Graphics 2011; 31(4): E77-E100.
- Johnson N, Hummelshoj L, Adamson G. World Endometriosis Society consensus on the classification of endometriosis. Hum Rep 2016; 32(2): 315-324.
- Ayala YR, González MM. Endometriosis: fisiopatología y líneas de investigación. Ginecol Obstet Mex 2007;75(8):477-83.
- Krina T, Phil D, Christian M, Stacey A. Endometriosis. NEJM 2020; 382:1244-56.
- Grümmer R, Schwarzer F, Bainczyk K. Peritoneal endometriosis: validation of an in-vivo model. Hum Rep 2001; 16(8): 1736-1743.
- Marco L, Fred M, Manuel L. Endometriosis peritoneal, ovárica e infiltrativa: una revisión. Rev Med UAS 2015; 5(2):72-88.
- Charles M, Errico Z, Andrea T. Endometriosis: advances and controversies in classification, pathogenesis, diagnosis and treatment. F1000 Faculty Rev 2019;529.
- Richard O, Linda C. Pathogenesis and Phatophysiology of endometriosis. Fertil Steril 2012. 98(3)511-9.
- Sachedina A, Todd N. Dysmenorrhea, Endometriosis and Chronic Pelvic Pain in Adolescents. J Clin Res Pediatr Endocrinol. 2020 Feb 6;12(Suppl 1):7-17.
- Gruber TM, Mechsner S. Pathogenes of Endometriosos: The origin of pain and subfertility. Cells 2021;10(6)1381.
- Morotti M, Vincent K, Becker CM. Mechanisms of pain in endometriosis. Eur J Obstet Gynecol Reprod Biol. 2017 Feb;209:8-13
- Kho RM, Andres MP, Borrelli GM, Neto JS, Zanluchi A, Abrão MS. Surgical treatment of different types of endometriosis: Comparison of major society guidelines and preferred clinical algorithms. Best Pract Res Clin Obstet Gynaecol. 2018 Aug;51:102-110.
- Canis M, Bourdel N, Botschorishvili R, Rabischong B et al. Endometrioma ovárico. EMC- Ginecología-Obstetricia 2015;52:1-15.
- Vimercati A, Achilarre M, Scardapane A. Accuracy of transvaginal sonography and contrast‐enhanced magnetic resonance‐colonography for the presurgical staging of deep infiltrating endometriosis. ISOUG 2012; 40(5): 592-603.
- Gambone J, Mittman B, Munro M. Chronic Pelvic Pain/Endometriosis Working Group. Consensus statement for the management of chronic pelvic pain and endometriosis: proceedings of an expert-panel consensus process. Fertnstert 2002; 78(5): 961-972.
- Mehedintu C, Plotogea MN, Ionescu S. Endometriosis still a challenge. J Med Life. 2014 Sep 15;7(3):349-57.
- Vercellini P, Crosignani P, Abbiati A. The effect of surgery for symptomatic endometriosis: the other side of the story. Hum Reprod 2009; 15(2): 177-188.
- Holland T, Yazbek J, Cutner A. Value of transvaginal ultrasound in assessing severity of pelvic endometriosis. Ultrasound Obstet Gynecol 2010; 36(2): 241-248.
- Guo S. Recurrence of endometriosis and its control. Hum Reprod 2009; 15(4): 441-461.
- Becker CM, Bokor A, Heikinheimo O. ESHRE Endometriosis Guideline Group. ESHRE guideline: endometriosis. Hum Reprod Open. 2022 Feb 26;2022(2):hoac009
- Goncalves M, Podgaec S, Dias Jr A. Transvaginal ultrasonography with bowel preparation is able to predict the number of lesions and rectosigmoid layers affected in cases of deep endometriosis, defining surgical strategy. Hum Reprod 2009; 25(3): 665-671.
- Ceccaroni M, Bounous VE, Clarizia R. Recurrent endometriosis: a battle against an unknown enemy. Eur J Contracept Reprod Health Care. 2019 Dec;24(6):464-474.
- Carvajal A, Braghetto I, Carvajal R, Miranda C. Endometriosis de la pared abdominal. Rev Chil Obstet Ginecol 2007; 72(2): 105-110.
- Sugarbaker PH. Peritonectomy procedures. Cancer Treat Res. 2007;134:247-64.
- Abesadze E, Sehouli J, Mechsner S, Chiantera V. Possible Role of the Posterior Compartment Peritonectomy, as a Part of the Complex Surgery, Regarding Recurrence Rate, Improvement of Symptoms and Fertility Rate in Patients with Endometriosis, Long-Term Follow-Up. J MInim Invasive Gynecol 2020; 27(5):1103-1111.
- de Arellano ML, Mechsner, S. The peritoneum—an important factor for pathogenesis and pain generation in endometriosis. J Mol Med 2014; 92: 595–602.