Rev Med UAS
Vol. 12: No. 2. Abril-Junio 2022
ISSN 2007-8013
Incremento en la mineralización valvular aórtica en pacientes con diabetes mellitus
Increased aortic valve mineralization in diabetes mellitus patients
Andrés Ramón Paniagua-Ávila1*, Martín Adrián Bolívar-Rodríguez2, Carlos Fernando Corona-Sapien3
- Médico Residente de segundo año de Cirugía General, Servicio de Cirugía General del Centro de Investigación y Docencia en Ciencias de la salud de la Universidad Autónoma de Sinaloa en el Hospital Civil de Culiacán
- Médico Especialista en Cirugía General, Jefe de División de Cirugía del Centro de Investigación y Docencia en Ciencias de la salud de la Universidad Autónoma de Sinaloa en el Hospital Civil de Culiacán
- Médico Especialista en Cardiología, Jefe de Servicio de Cardiología del Centro de Investigación y Docen-cia en Ciencias de la salud de la Universidad Autónoma de Sinaloa en el Hospital Civil de Culiacán
* Correspondencia: Andrés Ramón Paniagua-Ávila
Calle Eustaquio Buelna 91, Colonia Gabriel Leyva C.P. 80030 Culiacán, Sinaloa, México.
Teléfono: (331)2927192, Correo electrónico: pani_13_@hotmail.com
DOI http://dx.doi.org/10.28960/revmeduas.2007-8013.v12.n2.009
Texto Completo PDF
Recibido 22 de septiembre 2021, aceptado 05 de marzo 2022
RESUMEN
La estenosis aórtica y la diabetes mellitus son enfermedades crónico-degenerativas que tienen un impacto importante en la morbimortalidad a nivel mundial. En las últimas décadas se ha presentado mayor prevalencia de estenosis aórtica en pacientes con diabetes mellitus. El riesgo de la progresión a enfermedad grave de la estenosis aórtica aumenta en estos pacientes, condicionando a reemplazo valvular como el único tratamiento. Por lo tanto, se requiere de comprensión extensa de la patogénesis de ambas enfermedades y la relación entre estas para designar abordajes preventivos y terapéuticos. Este artículo de revisión busca la comprensión y actualización de la influencia de la diabetes mellitus en pacientes con estenosis aórtica degenerativa, así como la progresión de la enfermedad y el abordaje diagnóstico y terapéutico.
Palabras clave: Estenosis aórtica, diabetes mellitus, válvula aórtica, cardiopatía, mineralización.
ABSTRACT
Aortic stenosis and diabetes mellitus are chronic degenerative diseases that has an important worldwide impact in morbidity and mortality. In the last decade, there has been an increase in the prevalence of aortic valve stenosis in diabetic patients. The risk of severity associated with aortic stenosis increases in this patients, conditioning patients to valve replacement as the only treatment. Therefore, an extensive understanding of the pathogenesis of both diseases and the relationship between them is required to designate preventive and therapeutic approaches. This review article seeks to understand and update the influence of diabetes mellitus in patients with degenerative aortic stenosis, as well as the progression of the disease and the diagnostic and therapeutic approach
Keywords: Aortic stenosis, diabetes mellitus, aortic valve, cardiopathy, mineralization.
REFERENCIAS
- Mourino-Alvarez L, Corbacho-Alonso N, Sas-tre-Oliva T, Corros-Vicente C, Solis, J, Tejerina T, et al. Diabetes Mellitus and Its Implications in Aortic Stenosis Patients. Int J Mol Sci. 2021;22(12):6212.
- Stritzke J, Linsel-Nitschke P, Markus MR, Ma-yer B, Lieb W, Luchner A, et al. Association between degenerative aortic valve disease and long-term exposure to cardiovascular risk fac-tors: Results of the longitudinal population-based KORA/MONICA survey. Eur Heart J. 2009;30(16):2044-53.
- Rajamannan NM, Bonow RO, Rahimtoola SH. Calcific aortic stenosis: an update. Nat Clin Pract Cardiovasc Med. 2007;4(5):254-62.
- Banovic M, Athithan L, McCann GP. Aortic stenosis and diabetes mellitus: An ominous combination. Diab Vasc Dis Res. 2019;16(4):310-23.
- Tango AM, Salmonsmith J, Ducci A, Burriesci G. Validation and Extension of a Fluid–Structure Interaction Model of the Healthy Aor-tic Valve. Cardiovasc Eng Technol. 2018;9(4):739-51.
- De Paulis R, Salica A. Surgical anatomy of the aortic valve and root-implications for valve re-pair. Ann Cardiothorac Surg. 2019;8(3):313-21.
- Rojas-Martínez R, Basto-Abreu A, Aguilar-Salinas CA, Zárate-Rojas E, Villalpando S, Ba-rrientos-Gutiérrez T. Prevalencia de diabetes por diagnóstico médico previo en México. Sa-lud Publica Mex. 2018;60(3):224-32.
- Kopytek M, Ząbczyk M, Mazur P, Undas A, Natorska J. Accumulation of advanced glyca-tion end products (AGEs) is associated with the severity of aortic stenosis in patients with concomitant type 2 diabetes. Cardiovasc Dia-betol. 2020;19(1):92.
- Larsson SC, Wallin A, Håkansson N, Stackel-berg O, Bäck M, Wolk A. Type 1 and type 2 diabetes mellitus and incidence of seven car-diovascular diseases. Int J Cardiol. 2018;262:66-70
- Dutta P, Lincoln J. Calcific Aortic Valve Disea-se: a Developmental Biology Perspective. Curr Cardiol Rep. 2018;20(4):21.
- Mathieu P, Boulanger MC. Basic mechanisms of calcific aortic valve disease. Can J Cardiol. 2014;30(9):982-93.
- Fernandez-Tresguerres Hernandez-Gil I, Alo-bera Gracia MA, Del Canto Pingarrón M, Blan-co Jerez L. Bases fisiológicas de la regenera-ción ósea II. El proceso de remodelado. Med Oral Patol Oral Cir Bucal. 2006;11(2):92-8.
- Bertazzo S, Gentleman E. Aortic valve calcifi-cation: A bone of contention. Eur Heart J. 2017;38(16):1189-93.
- Testuz A, Nguyen V, Mathieu T, Kerneis C., Arangalage, D, Kubota N. et al. Influence of metabolic syndrome and diabetes on progres-sion of calcific aortic valve stenosis. Int J Car-diol. 2017;244:248-53.
- Zheng KH, Tsimikas S, Pawade T, Kroon J, Jenkins WSA, Doris MK, et al. Lipoprotein(a) and Oxidized Phospholipids Promote Valve Calcification in Patients With Aortic Stenosis. J Am Coll Cardiol. 2019;73(17):2150-62.
- Carrion K, Dyo J, Patel V, Sasik R, Mohamed SA, Hardiman G, et al. The long non-coding HOTAIR is modulated by cyclic stretch and WNT/β-CATENIN in human aortic valve cells and is a novel repressor of calcification genes. PLoS One. 2014;9(5):e96577.
- Coffey S, Cox B, Williams MJ. The prevalence, incidence, progression, and risks of aortic val-ve sclerosis: a systematic review and meta-analysis. J Am Coll Cardiol. 2014 Jul 1;63(25 Pt A):2852-61.
- Lindman BR, Clavel MA, Mathieu P, Iung B, Lancellotti P, Otto CM, et al. Calcific aortic ste-nosis. Nat Rev Dis Primers. 2016;2:16006.
- Rogers MA, Aikawa E. Cardiovascular calcifi-cation: artificial intelligence and big data acce-lerate mechanistic discovery. Nat Rev Cardiol. 2019;16(5):261-74.
- Thaden JJ, Nkomo VT, Enriquez-Sarano M. The Global Burden of Aortic Stenosis. Prog Cardiovasc Dis. 2014;56(6):565-71.
- Singh A, Chan DCS, Greenwood JP, Dawson DK, Sonecki P, Hogrefe K, et al. Symptom On-set in Aortic Stenosis: Relation to Sex Differen-ces in Left Ventricular Remodeling. JACC Car-diovasc Imaging. 2019;12(1):96-105.
- Vollema EM, Sugimoto T, Shen M, Tastet L, Ng ACT, Abou R, et al. Association of Left Ventricular Global Longitudinal Strain With Asymptomatic Severe Aortic Stenosis: Natural Course and Prognostic Value. JAMA Cardiol. 2018;•(9):839-47.
- Zheng KH, Tzolos E, Dweck MR. Pathophysio-logy of Aortic Stenosis and Future Perspecti-ves for Medical Therapy. Cardiol Clin. 2020;38(1):1-12.
- Jander N, Minners J, Holme I, Gerdts E, Bo-man K, Brudi P, et al. Outcome of Patients With Low-Gradient “Severe” Aortic Stenosis and Preserved Ejection Fraction. Circulation. 2011;123(8):887-95.
- White B, Wessel S, Zheng W, Gonzalez D, Sovari A, Konda S, et al. Quantitative analysis of spectral Doppler clicks in assessment of aortic stenosis. Echocardiography. 2019;36(12):2158-66.
- Joseph J, Naqvi SY, Giri J, Goldberg S. Aortic Stenosis: Pathophysiology, Diagnosis, and Therapy. Am J Med. 2017;130(3):253-63.
- Langanay T, Rouzé S, Tomasi J, Aymami M, Rehman SM, Anselmi A, et al. Conventional aortic valve replacement in 2005 elderly pa-tients: A 32-year experience. Eur J Cardiotho-rac Surg. 2018;54(3):446-52.
- Otto CM, Nishimura RA, Bonow RO, Carabello BA, Erwin JP 3rd, Gentile F, et al. 2020 ACC/AHA Guideline for the Management of Patients with Valvular Heart Disease: Executive Summary: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Cir-culation. 2021;143(5):e35-e71.
- Nishimura RA, Otto CM, Bonow RO, Carabello BA, Erwin JP 3rd, Guyton RA, et al. 2014 AHA/ACC Guideline for the Management of Patients With Valvular Heart Disease: Executi-ve summary: A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation. 2014;129(23):2440-92.
- Kang DH, Park SJ, Lee SA, Lee S, Kim DH, Kim HK, et al. Early Surgery or Conservative Care for Asymptomatic Aortic Stenosis. N Engl J Med. 2020;382(2):111-9.
- Mathieu P, Boulanger MC, Bouchareb R. Mo-lecular biology of calcific aortic valve disease: towards new pharmacological therapies. Expert Rev Cardiovasc Ther. 2014;12(7):851-62.
- Sen J, Chung E, Neil C, Marwick T. Antihyper-tensive therapies in moderate or severe aortic stenosis: a systematic review and meta-analysis. BMJ Open. 2020;10:e036960.
- Kodali SK, Williams MR, Smith CR, Svensson LG, Webb JG, Makkar RR, et al. Two-Year Outcomes after Transcatheter or Surgical Aor-tic-Valve Replacement. N Engl J Med. 2012;366(18):1686-95.
- Makkar RR, Thourani VH, Mack MJ, Kodali SK, Kapadia S, Webb JG, et al. Five-Year Outco-mes of Transcatheter or Surgical Aortic-Valve Replacement. N Engl J Med. 2020;382(9):799-809.
- Wernly B, Zappe AK, Unbehaun A, Sinning JM, Jung C, Kim WK, et al. Transcatheter valve-in-valve implantation (VinV-TAVR) for failed sur-gical aortic bioprosthetic valves. Clin Res Car-diol. 2019;108(1):83-92.