Rev Med UAS
Vol. 11: No. 3. Julio-Septiembre 2021
ISSN 2007-8013

Eficacia del tratamiento tópico de la tiña del pie con aceite de oliva ozonizado vs ketoconazol 2%.

Efficacy of topical treatment of ringworm of the foot with olive oil ozonated vs ketoconazole 2%.

Muñoz-Estrada Víctor Fernando1, Muñoz-Muñoz Rosalba2*

  1. Jefe de servicio de Dermatología
  2. Residente de la Especialidad en Dermatología

Centro de Investigación y Docencia en Ciencias de Ciencias de la salud. Hospital civil de Culiacán. Universidad Autónoma de Sinaloa. Culiacán, Sinaloa, México.

*Autor de correspondencia:Muñoz-Muñoz Rosalba
Correo Electrónico: rosalbamumu88@gmail.com
Dirección: Eustaquio Buelna 91, Burocrata, 80030 Culiacán Rosales, Sin.

DOI http://dx.doi.org/10.28960/revmeduas.2007-8013.v11.n3.002

Texto Completo PDF

Recibido 13 de Enero 2021, aceptado 14 de Mayo 2021

RESUMEN
Introducción: La tiña del pie o tinea pedis, es una micosis superficial, que afecta la planta y/o el dorso de los pies, así como el área interdigital. Es causada por hongos dermatofitos. Predomina en varones entre la tercera y la sexta década de la vida, afecta generalmente ambos pies, sobre todo en plantas y área interdigital, constituida por eritema, escama y descamación, frecuentemente pruriginosa. Debido a la notable capacidad germicida, se ha extendido el uso de aceites vegetales ionizados para el tratamiento de diversas afecciones micóticas, entre ellas la tiña podal. --- Material y Métodos: Se realizó un ensayo clínico controlado y aleatorizado. Se incluyeron todos los pacientes mayores de 18 años de edad con diagnóstico de tiña de pie y posteriormente se dividieron en dos grupos de tratamiento. Al primer grupo de pacientes se indicó ketoconazol en crema al 2% y al segundo grupo se indicó aceite de oliva ozonizado de 1000 mEq/L. --- Resultados: Se diagnosticaron 189 pacientes con Tiña del pie. La variedad clínica más frecuente fue la interdigital y el agente que se aisló con mayor frecuencia fue T. Rubrum. Presentaron curación completa a las 4 semanas de tratamiento de ketoconazol n=74 (77.8%) mientras que en el grupo de pacientes tratados con aceite ozonizado presentaron curación completa n=70 (74.4%) se calculó el valor de p=0-580. --- Conclusiones: No se encontró diferencia estadísticamente significativa entre los grupos de tratamiento.
Palabras clave: tiña podal, ketoconazol, aceite ozonizado.

ABSTRACT
Introduction: Tinea pedis, or tinea pedis, is a superficial mycosis, which affects the plant and / or the back of the feet, as well as the interdigital area. It is caused by dermatophyte fungi. It predominates in males between the third and sixth decade of life, usually affects both feet, especially in plants and interdigital area, consisting of erythema, flaking and scaling, often pruritic. Due to the remarkable germicidal capacity, the use of ionized vegetable oils has been extended for the treatment of various mycotic conditions, among them tinea pedis. --- Material and Methods: A randomized, controlled clinical trial was conducted. All patients over 18 years of age diagnosed with tinea pedis were included and divided into two treatment groups. Ketoconazole in 2% cream was indicated in the first group of patients and ozonized olive oil of 1000 mEq / L was indicated in the second group. Results: A total of 189 patients with Tinea capitis were diagnosed. The most frequent clinical variety was interdigital and the agent that was isolated most frequently was T. Rubrum. They presented complete cure at 4 weeks of treatment of ketoconazole n = 74 (77.8%) while in the group of patients treated with ozonated oil they had complete healing n = 70 (74.4%), p= 0-580. --- Conclusions: No statistically significant difference was found between the treatment groups.
Key words: tinea pedis, ketoconazole, ozonized oil

REFERENCIAS

  1. Zamani S, Sadeghi G, Yazdinia F, Moosa H, Pazooki A, Ghafarinia Z, et al. Epidemiological trends of dermatophytosis in Tehran, Iran: A five-year retrospective study. J Mycol Med. 2016;26(4):351-8.
  2. Hayette M-P, Sacheli R. Dermatophytosis, Trends in Epidemiology and Diagnostic Approach. Current Fungal Infection Reports. 2015;9(3):164-79
  3. Ilkit M, Durdu M. Tinea pedis: the etiology and global epidemiology of a common fungal infection. Crit Rev Microbiol. 2015;41(3):374-88.
  4. Lopez-Martinez R, Manzano-Gayosso P, Hernandez-Hernandez F, Bazan-Mora E, Mendez-Tovar LJ. Dynamics of dermatophytosis frequency in Mexico: an analysis of 2084 cases. Med Mycol. 2010;48(3):476-9.
  5. Gómez Moyano E, Crespo Erchiga V, Martínez Pilar L. Dermatofitosis. Piel. 2016;31(8):546-59.
  6. García-Romero MT, Arenas R. New insights into genes, immunity, and the occurrence of dermatophytosis. J Invest Dermatol. 2015;135:655–7.
  7. Jaradat SW, Cubillos S. Krieg Low DEFB4 copy number and high systemic hBD-2 and IL-22 levels are associated with dermatophytosis. J Invest Dermatol. 2014;135:750–8
  8. Ali-Shtayeh MS, Yaish S, Jamous RM, Arda H, Husein EI. Updating the epidemiology of dermatophyte infections in Palestine with special reference to concomitant dermatophytosis. J Mycol Med. 2015;25(2):116-22.
  9. Arenas R. Dermatofitosis en México. Rev iberoam Micol 2002; 19: 63-67.
  10. Kutlubay Z, Yardimci G, Kantarcioglu AS, Serdaroglu S. Acral manifestations of fungal infections. Clin Dermatol. 2017;35(1):28-39.
  11. Moureu S, Violleau F, Ali Haimoud-Lekhal D, Calmon A. Ozonation of sunflower oils: impact of experimental conditions on the composition and the antibacterial activity of ozonized oils. Chem Phys Lipids. 2015;186:79-85.
  12. Díaz Gómez MF, Ledea Lozano OE, Gómez Regüeiferio M, Garcés Mancheño R, Alaiz Barragán MS, Martínez Force E. Estudio comparativo de la ozonización de aceites de girasol modificados genéticamente y sin modificar J Química Nova. 2009;32:2467-72.
  13. Menendez S, Falcon L, Maqueira Y. Therapeutic efficacy of topical OLEOZON(R) in patients suffering from onychomycosis. Mycoses. 2011;54(5):e272-7.
  14. Bocci V, Borrelli E, Travagli V, Zanardi I. The ozone paradox: ozone is a strong oxidant as well as a medical drug. Med Res Rev. 2009;29(4):646-82.
  15. Campanati A, De Blasio S, Giuliano A, Ganzetti G, Giuliodori K, Pecora T, et al. Topical ozonated oil versus hyaluronic gel for the treatment of partial- to full-thickness second-degree burns: A prospective, comparative, single-blind, non-randomised, controlled clinical trial. Burns. 2013;39(6):1178-83.
  16. Bocci V. Is it true that ozone is always toxic? The end of a dogma. Toxicol Appl Pharmacol. 2006;216(3):493-504.
  17. Burgassi S, Zanardi I, Travagli V, Montomoli E, Bocci V. How much ozone bactericidal activity is compromised by plasma components? J Appl Microbiol. 2009;106(5):1715-21.
  18. Lu J, Guo M, Ligui H, Wu K, Xiang Y, Huang J, et al. Efficacy of combination of ozonated water with oil for treatment of tinea pedis. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2018;43(2):147-51.
  19. Travagli V, Zanardi I, Valacchi G, Bocci V. Ozone and ozonated oils in skin diseases: a review. Mediators Inflamm. 2010;2010:610418.
  20. Mutluoglu M, Karabacak E, Karagoz H, Uzun G, Ay H. Topical ozone and chronic wounds: improper use of therapeutic tools may delay wound healing. N Am J Med Sci. 2012;4(11):615-6.
  21. Aerts O, Leysen J, Horst N, Lambert J, Goossens A. Contact dermatitis caused by pharmaceutical ointments containing 'ozonated' olive oil. Contact Dermatitis. 2016;75(2):123-6.
  22. Valacchi G, Zanardi I, Lim Y, Belmonte G, Miracco C, Sticozzi C, et al. Ozonated oils as functional dermatological matrices: effects on the wound healing process using SKH1 mice. Int J Pharm. 2013;458(1):65-73.
  23. Valacchi G, Fortino V, Bocci V. The dual action of ozone on the skin. Br J Dermatol. 2005;153(6):1096-100.
  24. Menendez S, Falcon L, Simon D, Landa NJM. Efficacy of ozonized sunflower oil in the treatment of tinea pedis. 2002;45(7‐8):329-32.
  25. Falcón Lincheta L, Daniel Simón R, Menéndez Cepero S, Landa Díaz N, Moya Duque S. Solución para la epidermofitosis de los pies en integrantes de las Fuerzas Armadas Revolucionarias %J Revista Cubana de Medicina Militar. 2000;29:98-102.